1·Despite his best efforts, however, he did not end up with quinine.
尽管他尽了最大的努力，他最终还是没有得到奎宁（一种治疗疟疾的药物）。
2·One of his sixth-grade students, a recent immigrant, was gradually falling behind, resisting his teacher's best efforts.
他的一个六年级学生是一个新移民，这名学生抵制他老师付出的最大努力，逐渐掉队。
3·Despite your best efforts, the first two steps might not work.
尽管你做了最大的努力，前两步可能不起作用。
4·Despite their best efforts, Greek banks still risk being swamped.
尽管做了最大的努力，希腊银行仍然有陷入泥潭的危险。
5·If reproductions of our best efforts are free, how can we keep going?
如果复制我们最好的努力成果都不花分毫，我们如何能持续下去呢？
6·Despite Brazil's best efforts, the Doha trade talks have stalled.
尽管巴西尽了最大的全力，但多哈谈判仍被搁置。
7·Sometimes, despite our best efforts, the outcome is not positive.
有时候，尽管我们尽力了，结果还是不尽如人意。
8·In this work, I pledge my own best efforts. And, today, I ask for yours.
在这项工作中，我保证将尽自己的最大努力，今天，我请各位也尽你们的最大努力。
9·Despite the best efforts of my supporters, the repeal passed the House.
尽管我的支持者尽了全力，废除考试的提案还是在州众议院获得通过。
10·They dropped out despite their best efforts before the end and you lost them”.
他们作了努力，但最后还是放弃了，而网站也失去了这些客户。